Further Developments on the Regioselective Synthesis of 3-Aroylindole Derivatives from <i>C</i>-Nitrosoaromatics and Alkynones: A Novel Synthetic Approach to Pravadoline, JWH-073, Indothiazinone Analogues and Related Compounds
نویسندگان
چکیده
An uncatalyzed and easily accessible synthetic approach for the preparation of 3-aroylindoles was investigated using nitrosoarenes aromatic terminal ethynyl ketones. Indole derivatives were produced in good yields excellent regioselectivity. Functionalizations indole products carried out affording highly valuable versatile compounds. The indolization protocol studied as a fundamental step pravadoline 1-butyl-3-(1-naphthoyl)indole (JWH-073), bioactive molecules showing antinociceptic properties.
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ژورنال
عنوان ژورنال: International Journal of Organic Chemistry
سال: 2022
ISSN: ['2161-4695', '2161-4687']
DOI: https://doi.org/10.4236/ijoc.2022.123011